Repurposing FDA-approved drugs may decrease fibrosis in butterfly disease

Matrix detachment recapitulates fibrotic phenotypes through the TGF? pathway. Credit: EMBO Molecular Medicine (2024). DOI: 10.1038/s44321-024-00048-8 “Recessive Dystrophic Epidermolysis Bullosa (RDEB) is the worst disease you’ve probably never heard of,” says dermatology researcher Andrew South, Ph.D.. RDEB patients and their families know just how horrible it can be. Epidermolysis bullosa (EB) diseases such as RDEB are a rare group of skin blistering diseases that also increase fibrosis, or scarring. Fibrosis is a normal part of the wound healing process. However, in RDEB patients, frequent skin sores lead to a buildup of scar tissue, causing the skin to become even more Read More