Wednesday, January 22, 2025

Distinct signaling pathway identified as key driver for epithelial cancer development

Side section of the skin with epidermal stem cells (green) with one particular clone in red. Cell nuclei are stained in blue, the white dashed lines indicate hair follicles. Credit: Peter Renz, University of Zurich A distinct signaling pathway called TNF-? drives the transformation of epithelial cells into aggressive tumor cells. During cancer progression, cells activate their own TNF-? program and become invasive. This finding could help to improve early detection and treatment of patients with cancers in skin, esophagus, bladder or colon, as University of Zurich (UZH) researchers state. How does a normal cell in the body develop into Read More

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