Model summarizing the function of PI3K? in antibody responses. Credit: Nature Immunology (2024). DOI: 10.1038/s41590-024-01890-1 A medical mystery served as the genesis for a Yale-led study that has promising implications for treating a range of autoimmune diseases. A young girl entered the clinic suffering from blood cell abnormalities, difficulty breathing, and later, diarrhea. She also had been diagnosed with recurrent infections due to low levels of antibody production. Her doctors treated her with corticosteroids to reduce her lung and gut inflammation and immunoglobulin replacement therapy to restore her antibody levels. The lab of Carrie Lucas, Ph.D., associate professor of immunobiology Read More
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