Obesity modifies link between birth weight, metabolic phenotypes

Associations between lower birth weight (BW) and adverse metabolic phenotypes are more pronounced in children with obesity, according to a study published in the July issue of eBioMedicine. Sara Elizabeth Stinson, Ph.D., from the University of Copenhagen in Denmark, and colleagues used data from the cross-sectional HOLBAEK Study with 4,263 participants to examine the modifying effect of childhood obesity on the association between BW and a polygenic score (PGS) for BW with cardiometabolic risk in children and adolescents. The researchers found that BW and a PGS for BW were associated with cardiometabolic risk and plasma protein levels in childhood and Read More