Scientists develop first bone marrow model that supports human stem cells

Schematic of the bone marrow (BM) niche microenvironment. Credit: Nature Communications (2024). DOI: 10.1038/s41467-024-50054-0 Scientists have created the first bioengineered bone marrow model that can support the type of human stem cells that are crucial for bone marrow transplants and in vitro study work. The research—published in Nature Communications and led by the University of Glasgow—replicates key aspects of the human bone marrow microenvironment, to enable the support of rare long-term hematopoietic stem cells, or LT-HSCs. LT-HSCs are vital for bone marrow transplants as they are the cell type that can replenish the blood cells after treatment for blood cancers. Read More