Study reveals dual role of protein in cancer treatment

Graphical abstract. Credit: Cell Reports (2024). DOI: 10.1016/j.celrep.2024.114289 Investigators at the UCLA Health Jonsson Comprehensive Cancer Center have uncovered new details about the role of a protein called interferon regulatory factor (IRF1) in cancer progression and treatment response, offering new insight that can potentially help improve the effectiveness of cancer immunotherapy. The study, published in Cell Reports, reveals how IRF1 can both hinder and help the body’s immune response to tumors, depending upon which cells the protein is found in. “We know IRF1 plays a pivotal role in modulating antiviral immunity,” said Dr. Philip Scumpia, associate professor of medicine at Read More