‘Paleolithic’ diets are not without risks, according to study

Lack of hepatic GDH induces phase advance of the circadian rhythm of respiratory exchange ratio (RER), which is exacerbated by high protein diet. Credit: Journal of Biological Chemistry (2024). DOI: 10.1016/j.jbc.2024.107473 High-protein diets, known as paleolithic diets, are popular. Using mouse models, scientists at the University of Geneva (UNIGE) have studied their impact. While effective in regulating weight and stabilizing diabetes, these diets are not without risks. Excess protein greatly increases ammonium production, overwhelming the liver. Excess ammonium can cause neurological disorders and, in severe cases, lead to coma. These results, published in the Journal of Biological Chemistry, suggest caution Read More