Modulating in vitro lung fibroblast activation via senolysis of senescent human alveolar epithelial cells

Summary of in vitro and ex vivo systems to mimic alveolar epithelial and fibroblast damage and dysfunction in the IPF lung. Credit: Aging (2024). DOI: 10.18632/aging.205994 A new research paper titled “Modulating in vitro lung fibroblast activation via senolysis of senescent human alveolar epithelial cells” has been published in Aging. Idiopathic pulmonary fibrosis (IPF) is an age-related disease with poor prognosis and limited therapeutic options. Activation of lung fibroblasts and differentiation to myofibroblasts are the principal effectors of disease pathology, but damage and senescence of alveolar epithelial cells, specifically type II (ATII) cells, has recently been identified as a potential Read More