Gut protein may protect brain cells in Parkinson’s disease

Functional GUCY2C protein and mRNA are expressed by DA neurons within the SNpc. a Schematic of mice used for analyses. b–d Immunofluorescence staining reveals that guanylyl cyclase C (GUCY2C) protein is expressed in 98% of tyrosine hydroxylase (TH)+ neurons, but not in astrocytes or microglia, in the mouse midbrain (n?=?3). Scale bars represent 20?µM. e–l Combined immunofluorescence and RNAscope identifies high levels of Gucy2c mRNA co-expressed with TH protein and mRNA. Scale bars represent 200?µM (e–h) or 20?µM (i–l). m Gucy2c mRNA is not expressed by TH-negative cells (n?=?3). n Gucy2c mRNA is expressed at nearly a third of Th Read More