The molecular mechanisms underlying cardiac repair

In summary, macrophages secrete IFN-?, activating the IFN-?-IFNAR-p-STAT1 axis in MICFs, leading to increased secretion of CCL2/7/12 chemokines and subsequent recruitment of more IFN-?-secreting macrophages. These recruited macrophages further enhance STAT1 phosphorylation, establishing a self-reinforcing positive feedback loop between MICFs and macrophages. Knockdown of IFNAR disrupts this loop, facilitating efficient reprogramming. Credit: Hao Wang, Junbo Yang, Yihong Cai, Yang Zhao A paper, “Macrophages suppress cardiac reprogramming of fibroblasts in vivo via IFN-mediated intercellular self-stimulating circuit,” published in Protein & Cell uncovers a previously unappreciated mechanism by which macrophages influence the fate of CFs post-MI. It demonstrates that macrophage-derived IFN-? stimulates Read More