Interdisciplinary team integrates crucial immune cells into heart-on-a-chip platform

Credit: Cell Stem Cell (2024). DOI: 10.1016/j.stem.2024.05.011 Researchers at the University of Toronto have discovered a novel method for incorporating primitive microphages—crucial immune cells—into heart-on-a-chip technology, in a potentially transformative step forward in drug testing and heart disease modeling. In a study published in Cell Stem Cell, an interdisciplinary team of scientists describe how they integrated the microphages—which were derived from human stem cells and resemble those found in the early stages of heart development—onto the platforms. These macrophages are known to have remarkable abilities in promoting vascularization and enhancing tissue stability. Corresponding author Milica Radisic, a senior scientist in Read More