Targeting deubiquitinase OTUB1 protects vascular smooth muscle cells in atherosclerosis by modulating PDGFR?

Credit: Frontiers of Medicine (2024). DOI: 10.1007/s11684-024-1056-8 A recent study investigates the role of the deubiquitinase OTUB1 in vascular smooth muscle cells (VSMCs) within the context of atherosclerosis, a disease characterized by lipid accumulation and plaque formation in arteries. Atherosclerosis is a major cause of cardiovascular and cerebrovascular diseases, with VSMCs playing a significant role in its development. The research explores the potential of targeting OTUB1 to modulate the phenotype switch of VSMCs, which is considered a critical pathological process in atherosclerosis. The research is published in the journal Frontiers of Medicine. Ubiquitylation, a post-translational modification, has been implicated in Read More