Human stem cell models point to glia as key players in multiple sclerosis

Glia-enriched cultures from a primary progressive multiple sclerosis iPSC line showing astrocytes (yellow), oligodendrocytes (cyan), and neurons (magenta). Credit: New York Stem Cell Foundation A team of scientists from The New York Stem Cell Foundation (NYSCF) Research Institute and Case Western Reserve University has created the largest reported collection of stem cell models from multiple sclerosis (MS) patients and used them to identify unique ways in which glia—integral support cells in the brain—contribute to the disease. The study, published today in Cell Stem Cell, is the first to report that glial cells from MS patients have intrinsic hallmarks of disease, Read More