Single-cell RNA sequencing reveals heterogeneity in fibrotic scars after spinal cord injury

Schematic diagram of fibrotic scar heterogeneity after spinal cord injury. Credit: Nature Communications (2024). DOI: 10.1038/s41467-024-50564-x Myofibroblasts generate fibrotic scars after spinal cord injury (SCI). This is typically regarded as an impediment to nerve regeneration. Understanding the heterogeneous characteristics of ?brotic scars might help to develop strategies for remodeling ?brotic scars after SCI. However, the composition, origin and function of fibrotic scars have been a subject of ongoing debate in the field. A recent study led by Profs. Dai Jianwu and Zhao Yannan from the Institute of Genetics and Developmental Biology of the Chinese Academy of Sciences employed a combination Read More