An ancient signaling pathway and 20 years of research offer hope for rare cancer

Credit: EMBO Reports (2024). DOI: 10.1038/s44319-024-00217-3 Researchers at Peter Mac are using their knowledge of an ancient signaling pathway to find new treatments for mesothelioma, a devastating cancer that has few effective treatments and a very poor prognosis. Dr. Kieran Harvey, Group Leader and Program Head at Peter Mac, helped discover the “Hippo” signaling pathway 20 years ago and has spent his career trying to understand more about how this pathway controls organ growth and how we can target it to treat cancer. There are currently five treatments being tested in early clinical trials that target the Hippo pathway, and Read More