Study reveals how cancer outsmarts immunity—and how to potentially turn the tables

Cell mapping by scRNA-seq of early and late tumors in a breast cancer GEMM. Credit: Nature Immunology (2024). DOI: 10.1038/s41590-024-01932-8 A new study led by researchers at Beth Israel Deaconess Medical Center (BIDMC) and Boston Children’s Hospital and published in Nature Immunology shows how tumors grow by avoiding the immune system. The researchers revealed how genes in tumors edit themselves to escape the immune system’s detection. The study identifies, for the first time, the actual genes that are silenced by tumors, offering a roadmap for better immunotherapies. The researchers studied breast cancer in a mouse model, using genome-wide single-cell RNA Read More