Mechanisms of antibody gene diversification during somatic hypermutation

AID-induced U/G lesions can be perfectly repaired or may result in C/G transition mutations via DNA replication, C/G transition or transversion mutations via the BER pathway, and A/T mutations via the MMR pathway. Credit: Science China Press In a recent online publication in Science China Life Sciences, researchers from the laboratory of Leng-Siew Yeap at the Shanghai Institute of Immunology, Shanghai Jiao Tong University School of Medicine published a review article entitled “Molecular Mechanisms of DNA Lesion and Repair During Antibody Somatic Hypermutation.” The review comprehensively summarizes the mechanisms involved in the generation of antigen-specific diversified antibodies, with a particular Read More