Gut dysbiosis found to impair intestinal renewal and lipid absorption in Scarb2 deficiency-associated neurodegeneration

Scarb2 deficiency is associated with alterations in gut microbiota composition and increased intestinal FXR signaling, leading to impairments in lipid absorption and the renewal of the intestinal epithelium. Inhibiting FXR signaling or correcting nutrient deficiency can alleviate neurodegenerative changes in Scarb2-/- mice. Credit: Yinghui Li, et al. A study published in the journal Protein & Cell details the connection between SCARB2 deficiency and gastrointestinal dysfunction, revealing that the loss of SCARB2 leads to alterations in bile acid metabolism and dysbiosis in the gut microbiome. This disruption affects the signaling pathway involving FXR, which normally regulates bile acid synthesis and intestinal Read More