Advances in detecting and treating rare genetic variants of colorectal cancer

Expression products and effects of rare mutated genes in CRC. (A) ERBB2 (HER2), (B) ALK, (C) ROS1, (D) NTRK1, NTRK2, and NTRK3, (E) RET, (F) EGFR, and (G) FGFR2 activate Ras-Raf-MAPK, PI3K-AKT, and PIP2-IP3 signaling pathways and ultimately facilitate cell migration, cell proliferation, gene expression, and drug resistance. Credit: Cancer Biology & Medicine Recent research highlights the importance of targeted therapies for treating advanced colorectal cancer (CRC) with rare genetic variants. These mutations, often linked to poor prognosis and limited response to conventional treatments, are being addressed through advanced sequencing technologies and new targeted drugs. This study explores the clinical Read More