Non Muscle Invasive Bladder Transitional Cancer (NMIBC) and Muscle Invasive Bladder Transitional Cancer (MIBC)/invasive have different gene profile and clinical course. NMIBC prognosis is not completely predictable, since the relapse rate is higher than 20%, even in the form of MIBC.
The aim…
Urotensin II receptor determines prognosis of bladder cancer regulating cell motility/invasion
Basaloid squamous cell carcinoma presents with a preference for the head and neck region, and shows a distinct aggressive behavior, with frequent local recurrences, regional and distant metastasis. The alterations in the cadherin-catenin complex are fundamental requirements for the metastasis…
Expression of E-cadherin and beta-catenin in basaloid and conventional squamous cell carcinoma of the oral cavity: are potential prognostic markers?
We have previously suggested a method for proteome wide analysis of variation at functional residues wherein we identified the set of all human genes with nonsynonymous single nucleotide variation (nsSNV) in the active site residue of the corresponding proteins. 34 of these proteins were shown…
A framework for application of metabolic modeling in yeast to predict the effects of nsSNV in human orthologs
The progression of low-risk del(5q) myelodysplastic syndrome to acute myeloid leukemia is increased when associated with mutations of TP53, or with additional chromosomal abnormalities. However, to date the prognostic impact and molecular consequences of these rearrangements were poorly…
FOXP1 and TP63 involvement in the progression of myelodysplastic syndrome with 5q- and additional cytogenetic abnormalities
[ | E-mail ] Contact: HU Xiaofengxfhu@vip.sina.comScience China Press The big data era bring the confusions, challenges and opportunities to the modeling and simulation field tightly associated with big data. The Chinese Association for System Simulation undertook the 81st new ideas…
Source:Modeling and simulation in the big data era
[ | E-mail ] Contact: Connie HughesConnie.Hughes@wolterskluwer.com 646-674-6348Wolters Kluwer Health Expert recommendations for advancing back pain research published in Spine June 3, 2014 – Standardized research methods are needed to make greater progress toward reducing the…
Source:NIH task force proposes standards for research on chronic low back pain
[ | E-mail ] Contact: Diana Yatesdiya@illinois.edu 217-333-5802University of Illinois at Urbana-Champaign IMAGE: The researchers tracked brain activity in participants using electroencephalography, which captures signals from dozens of electrodes on the scalp. Click…
Source:Brain signals link physical fitness to better language skills in kids
[ | E-mail ] Contact: Diana Yatesdiya@illinois.edu 217-333-5802University of Illinois at Urbana-Champaign IMAGE: University of Illinois crop sciences professor Aaron Hager is warning Illinois farmers about Palmer amaranth, an invasive weed that can take over farm fields in…
Source:Palmer amaranth threatens Midwest farm economy, researchers report
[ | E-mail ] Contact: Albert Angpress@inderscience.comInderscience Publishers As the developing world continues to develop, standards of living and access to technology increases. Unfortunately, as personal computers, laptops and mobile phones become increasingly common so the problem…
Source:Toxic computer waste in the developing world
[ | E-mail ] Contact: Connie HughesConnie.Hughes@wolterskluwer.com 646-674-6348Wolters Kluwer Health More research needed to establish the effectiveness of training and naloxone distribution June 3, 2014 Community opioid overdose prevention programs (OOPPs)including the use of naloxone…
Source:Opioid overdose prevention programs may reduce deaths, reports Journal of Addiction Medicine
WASHINGTON (AP) — President Barack Obama’s plan to curb power plant pollution put Democrats running for office in coal country in a tough spot on Monday: Criticize their president, or side with him and become part of what could be a major drag on their region’s…
Source:Pollution rule tricky for coal country Democrats
In a revolutionary new design, condoms significantly reduced in length could increase sensation while protecting against unwanted pregnancy and sexually transmitted infections (STIs). The Galactic Cap is exactly that, a cap that covers the uppermost part of the glans penis, held in…
Source:Galactic Cap reinvents condom design for better sensation
The stress and strain of constantly being connected can sometimes take your life — and your well-being — off course. GPS For The Soul can help you find your way back to balance. GPS Guides are our way of showing you what has relieved others’ stress in the hopes that…
Source:This Playlist Will Help You Embrace Life’s Changes
By John Tilak (Reuters) – Canada’s main stock index was little changed on Tuesday as a gain in shares of energy producers was offset by weakness in the materials sector after copper and gold prices slipped. The market appeared to be directionless, with investors looking…
Source:TSX steady as energy shares gain, miners slip
The rear view of Hugh Jackman’s portrayal of Wolverine character evokes audible sighs from the X-Men audience. That magnificent sight is, however, no surprise to anyone who saw Jackman’s Tony Award-winning performance in The Boy from Oz. His maraca- and booty-shaking…
Source:Hugh Jackman: Adamantium Claws, Heart of Gold
By Maryann McLaughlin, MD, MPH, FACC Medical Director, Cardiac Health Program Mount Sinai Health System Most people know that post-menopausal women and smokers are at risk for heart disease, and that having diabetes, and high cholesterol and blood pressure, can be contributing factors….
Source:Heart Disease in Women: What You Need to Know
Pigs feeding at a farm in Indiana. (REUTERS/John Gress) Swine veterinarian Bill Minton thought the baby pigs dying at a farm in western Ohio had a bad case of gastro-enteritis and was stumped when lab results came back with no indication of what had killed them. It took nearly 30 days – and…
Source:Mystery over origins of pig virus contributes to spread and anxiety
Our kitchen cabinets are filled with spices, yet we tend to take them for granted. Spices can do a lot more than flavor your dinner. Some spices can help reduce inflammation, stop a bloody nose, or soothe an achy stomach. Here are some super spices that pack more health benefits than you might…
Source:5 spices to keep in your medicine cabinet
Young women may have worse long-term outcomes than men after suffering a heart attack. In new research presented at the American Heart Association’s Quality of Care and Outcomes Research Scientific Sessions 2014, researchers evaluated data from 3,501 patients aged 55 and under who had an…
Source:Women fare worse than men after heart attack
(Reuters) – Prosensa Holding NV said the U.S. Food and Drug Administration had outlined an accelerated regulatory approval path for its most advanced drug, aimed at treating a muscle disorder. The Netherlands-based company said on Tuesday it planned to conduct two more studies, and…
Source:FDA sets approval path for Prosensa muscle disorder drug
CHICAGO (Reuters) – Britain’s AstraZeneca Plc on Tuesday said data from early-stage trials of its experimental cancer drug, MEDI4736, are encouraging and support moving the immunotherapy into pivotal-stage testing. The findings were part of a series of presentations by…
Source:Cancer drug data supports advanced trials: AstraZeneca
RIYADH (Reuters) – Saudi Arabia said on Tuesday that a review of health data had identified an additional 113 confirmed cases of the sometimes deadly Middle East Respiratory Syndrome (MERS) that had not been previously recorded, bringing the total to 688. The death toll in the kingdom…
Source:Saudi Arabia says has 113 more MERS cases than previously thought
TUESDAY June 3, 2014, 2014 — Gender may play a part in how much pain a patient feels following surgery, new research suggests. An Austrian study involving more than 10,000 people found that men experience more pain after major surgery, while women report feeling more pain following minor…
Source:Men Feel More Pain After Major Surgeries, Study Finds
TUESDAY June 3, 2014, 2014 — Researchers working with mice have identified a drug they believe holds promise as a preventive treatment for Alzheimer’s disease. In the study, the compound cut levels of amyloid beta — a protein associated with this degenerative brain disease…
Source:Anti-Alzheimer’s Drug Shows Promise in Mice Study
A new study from the University of Colorado Denver shows public health issues are often ignored in many transportation projects, especially when major roads are built through lower-income neighborhoods.
Air pollution, crime and numerous traffic hazards, the study said, point to a serious and…
Study shows public health often ignored in transportation policy
There appears to be no link between chronic cerebrospinal venous insufficiency and multiple sclerosis (MS), according to new research published in CMAJ (Canadian Medical Association Journal).
In 2009, Dr. Paolo Zamboni postulated that chronic cerebrospinal venous insufficiency is a cause of MS,…
No apparent link between chronic cerebrospinal venous insufficiency and MS
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Recipes for Health: Asparagus, Green Beans and Potatoes With Green Mole Sauce
WASHINGTON (Reuters) – Two lawmakers from the coal-producing state of West Virginia said on Monday they plan legislation to stop rules to set caps on carbon emissions from U.S. power plants. Representative Nick Rahall, a Democrat, will work with Representative David McKinley, a…
Source:West Virginia lawmakers say will fight EPA carbon rule
By Emily Stephenson WASHINGTON (Reuters) – The U.S. Federal Reserve has hired a former state insurance commissioner to help it oversee non-bank financial firms that a council of regulators identified for tougher scrutiny last year. Thomas Sullivan, who led the Connecticut…
Source:Exclusive: U.S. Fed hires former insurance regulator to help oversee AIG, Prudential
WASHINGTON (AP) — In a sweeping initiative to curb pollutants blamed for global warming, the Obama administration unveiled a plan Monday aimed at cutting carbon dioxide emissions from power plants by nearly a third by 2030. But it delays the deadline for some states to begin complying…
Source:Big power-plant pollution cuts are ordered
Eating ice actually burns calories, says an expert.AP Photo/Martin Meissner Not only does ice offer a calorie-free way to snack—it actually burns calories as your body melts it, says an expert. Gastroenterologist Dr. Brian Weiner steers patients away from fad diets, but his findings on ice…
Source:The new diet trend: eating ice?
A patient receives chemotherapy treatment for breast cancer.REUTERS/Eric Gaillard Chemotherapy is a powerful weapon against cancer, but it can also have lasting effects First used to treat cancer in the 1950s, chemotherapy drugs use powerful chemicals to kill cancer cells and inhibit them from…
Source:Chemotherapy: How cancer drugs impact the body long-term
A genetic mutation that codes for the blond hair of Northern Europeans has been identified. The single mutation was found in a long gene sequence called KIT ligand (KITLG) and is present in about one-third of Northern Europeans. People with these genes could have platinum blond, dirty blond or…
Source:Scientists identify ‘blond gene’
(Reuters) – New data on Bristol-Myers Squibb Co’s melanoma drug Yervoy, including fresh results from an effort to combine it with another promising cancer immunotherapy, suggest it can improve treatment for patients with both advanced and slightly earlier stage disease, according…
Source:Bristol’s Yervoy, alone or in combo, improves melanoma results: studies
(Reuters) – A highly anticipated new immunotherapy from Merck Co Inc proved effective in patients with advanced melanoma as well as some with lung cancer or head and neck cancer, according to early-stage studies presented on Monday. Merck filed in January for U.S. Food and Drug…
Source:Merck immune system-booster effective in skin, lung cancer
PARIS (Reuters) – France has started a six-month experiment with paying people to cycle to work, joining other European governments in trying to boost bicycle use to boost people’s health, reduce air pollution and cut fossil fuel consumption. Several countries including the…
Source:France experiments with paying people to cycle to work
MONDAY June 2, 2014, 2014 — The Obama administration announced plans Monday that would require the United States to cut power plant emissions that many scientists blame for global warming by 30 percent by 2030. It’s a move that would substantially improve the health of millions of…
Source:Obama Moves to Cut Power Plant Emissions
MONDAY June 2, 2014, 2014 — People may soon be able to learn whether or not they have lung cancer — and how bad their cancer is — by breathing into a tube. Researchers have developed a breathalyzer that can detect lung cancer and assess whether it is early or advanced,…
Source:Breath Test May Spot Lung Cancer
MONDAY June 2, 2014, 2014 — A pill that blocks male hormone activity can improve survival and delay the need for chemotherapy in men with advanced prostate cancer, a new clinical trial has found. Men who took a daily dose of the drug enzalutamide started chemotherapy nearly a year and a…
Source:New Drug May Boost Survival for Advanced Prostate Cancer Patients: Study
Monday June 2 2014
Around 1 in 500 women carry the BRAC2 breast cancer gene
“Smoking and the breast cancer risk gene BRCA2 combine to…
Breast cancer gene and smoking is a ‘lethal mix’
(Reuters) – New data on Bristol-Myers Squibb Co’s melanoma drug Yervoy, including fresh results from an effort to combine it with another promising cancer immunotherapy, suggest it can improve treatment for patients with both advanced and slightly earlier stage disease, according…
Bristol’s Yervoy, alone or in combo, improves melanoma results: studies
(Reuters) – A highly anticipated new immunotherapy from Merck Co Inc proved effective in patients with advanced melanoma as well as some with lung cancer or head and neck cancer, according to early-stage studies presented on Monday.
Merck filed in January for U.S. Food and Drug…
Merck immune system-booster effective in skin, lung cancer
PARIS (Reuters) – France has started a six-month experiment with paying people to cycle to work, joining other European governments in trying to boost bicycle use to boost people’s health, reduce air pollution and cut fossil fuel consumption.
Several countries including the…
France experiments with paying people to cycle to work
MONDAY June 2, 2014, 2014 — The Obama administration announced plans Monday that would require the United States to cut power plant emissions that many scientists blame for global warming by 30 percent by 2030.
It’s a move that would substantially improve the health of millions of…
Obama Moves to Cut Power Plant Emissions
MONDAY June 2, 2014, 2014 — A pill that blocks male hormone activity can improve survival and delay the need for chemotherapy in men with advanced prostate cancer, a new clinical trial has found.
Men who took a daily dose of the drug enzalutamide started chemotherapy nearly a year and a…
New Drug May Boost Survival for Advanced Prostate Cancer Patients: Study
MONDAY June 2, 2014, 2014 — People may soon be able to learn whether or not they have lung cancer — and how bad their cancer is — by breathing into a tube.
Researchers have developed a breathalyzer that can detect lung cancer and assess whether it is early or advanced,…
Breath Test May Spot Lung Cancer
Reasons may include spending more time alone, eating junk food Children who eat breakfast and dinner with parents are less likely to be fat But those who eat lunch with their parents are more likely to be overweight By Emma Innes Published: 09:15 EST, 2 June 2014 | Updated: …
Source:Divorce could make your children FAT: Kids of separated parents are 1.5 times more likely to be overweight
Women who get sunburn that blisters at least five times between the ages of 15 and 20 are 80% more likely to develop melanoma in their lifetimes They are also 68% more likely to develop less aggressive skin cancers UV radiation exposure in later life does not affect melanoma risk But it does…
Source:Getting badly sunburnt just FIVE times as teen makes you 80% more likely to develop skin cancer
Georgina Baird, 26, from Southampton, weighed 17st 8lb and was a size 20 Simon Clayton, 56, offered to pay for a boob job to help her lose weight Full time mother-of-three is now a slender size eight and weighs just 8st Reveals operation was the motivation she needed to shed the pounds Says Mr…
Source:Woman sheds HALF her weight after father promised to pay for boob job if she reached target
The proposed Keystone XL pipeline has generated controversy, especially in Nebraska, where opposition to transporting crude from the oil sands of Canada has delayed a national decision on the project.
Source:Even If Keystone Pipeline Rejected, Oil May Still Cross Neb. By Rail
i i hide captionThe EPA is proposing rules that would govern carbon dioxide gas emissions by U.S. power plants. Here, coal is transported via conveyor belt to the coal-fired Jim Bridger Power Plant outside Point of the Rocks, Wyo., in March. Jim…
Source:EPA Unveils New Proposal Targeting Greenhouse Gases
Nipah virus and Hendra virus are closely related and following natural or experimental exposure induce similar clinical disease. In humans, encephalitis is the most serious outcome of infection and, hitherto, research into the pathogenesis of henipavirus encephalitis has been limited by the…
Source:Subclinical infection without encephalitis in mice following intranasal exposure to Nipah virus-Malaysia and Nipah virus-Bangladesh
Alzheimer’s disease (AD) is a progressive, incurable neurodegenerative disease and the most commontype of dementia. It cannot be prevented, cured or drastically slowed, even though AD research hasincreased in the past 5-10 years. Instead of focusing on the brain volume or on the single…
Source:Brain region’s relative proximity as marker for Alzheimer’s disease based on structural MRI
Allogeneic stem cell transplant recipients are prone to infections by various organisms. Tuberculosis (TB) represents a rare infectious complication, especially in countries non-endemic for TB.Case report: Here, we report the case of a German patient with exposure to TB decades before he was…
Source:Synchronous tuberculosis, Epstein-Barr virus-associated lymphoproliferative disorder and cytomegalovirus infection in an allogeneic transplant recipient: a case report
Djungarian hamster (P. sungorus) and Roborovskii hamster (P. roborovskii) belong to the same genus of phodopus. Roborovskii hamster shows high locomotor activity and low level of dopamine (DA) in the brain. Administration of L-tyrosine, a precursor of DA, decreases locomotor activity in…
Source:Metabolism of amino acids differs in the brains of Djungarian hamster (P. sungorus) and Roborovskii hamster (P. roborovskii)
The Patient Satisfaction Questionnaire (PSQ) is an assessment tool used to evaluate patients’perspectives of their doctor’s communication and interpersonal skills. The present pilot study investigated whether the PSQ could be administered successfully in a hospice inpatient setting…
Source:Is the patient satisfaction questionnaire an acceptable tool for use in a hospice inpatient setting?: a pilot study
Here’s more evidence that pregnant women should be careful about what they eat and drink: A new research report appearing in the June 2014 issue of The FASEB Journal shows that when taken during pregnancy, resveratrol supplements led to developmental abnormalities in the fetal pancreas….
Source:'Healthy' component of red wine, resveratrol, causes pancreatic abnormalities in fetuses
Until now, scientists have not known exactly how inflammation weakens the Blood-Brain Barrier, allowing toxins and other molecules access to the brain. A new research report appearing in the June 2014 issue of The FASEB Journal solves this mystery by showing that a molecule, called…
Source:Why inflammation leads to a leaky blood-brain barrier: MicroRNA-155
Obese, Caucasian females over age 50 with diabetes and on dialysis because their kidneys have failed are among those at highest risk for the rare and deadly condition calciphylaxis, according to an analysis of the United States Renal Data System. Calciphylaxis occurs when calcium and phosphorus…
Source:Obese, older, Caucasian women on dialysis most at risk for rare, deadly condition
It was found that women who had five or more blistering sunburns between age 15 and 20 years old had a 68 per cent increased risk for basal cell carcinoma (BCC) and squamous cell carcinoma (SCC), and 80 per cent increased risk of melanoma. Dr. Qureshi said: “Our results suggest…
Source:Suffering sunbun five times increase skin cancer risk
CHICAGO (AP) — It’s National Cancer Survivors Day, and chances are good that you know at least one of them. Cancer survivors now number more than 14.5 million in the United States and are expected to grow to 19 million over the next decade, a new report finds. More cancers are…
Source:There Are Now More Than 14.5 Million Cancer Survivors In The U.S.
You might think this bit would be easy, but one of the hardest things about our working lives is knowing what we ideally want to do with them. It’s simple enough to sense what is boring and soul-destroying, but identifying what would satisfy us is a greater challenge. It’s a good…
Source:A Guide To The Pleasures Of Work
TRENTON, N.J. (AP) — For decades, seasonal allergy sufferers had two therapy options to ease the misery of hay fever. They could swallow pills or squirt nasal sprays every day for brief reprieves from the sneezing and itchy eyes. Or they could get allergy shots for years to gradually…
Source:New Allergy Tablets Offer Alternative To Shots
CHICAGO (AP) — A cheap, decades-old chemotherapy drug extended life by more than a year when added to standard hormone therapy for men whose prostate cancer has widely spread, doctors reported Sunday. Men who received docetaxel, sold as Taxotere and in generic form, lived nearly 58…
Source:This Cheap, Decades-Old Drug Greatly Boosts Prostate Cancer Survival
Women who get sunburn that blisters at least five times between the ages of 15 and 20 are 80% more likely to develop melanoma in their lifetimes
They are also 68% more likely to develop less aggressive skin cancers
UV radiation exposure in later life does not affect melanoma risk
But it does…
Getting badly sunburnt just FIVE times as teen makes you 80% more likely to develop skin cancer
Reasons may include spending more time alone, eating junk food
Children who eat breakfast and dinner with parents are less likely to be fat
But those who eat lunch with their parents are more likely to be overweight
By
Emma Innes
Published:
09:15 EST, 2 June 2014
Georgina Baird, 26, from Southampton, weighed 17st 8lb and was a size 20
Simon Clayton, 56, offered to pay for a boob job to help her lose weight
Full time mother-of-three is now a slender size eight and weighs just 8st
Reveals operation was the motivation she needed to shed the pounds
Says Mr…
Woman sheds HALF her weight after father promised to pay for boob job if she reached target
The proposed Keystone XL pipeline has generated controversy, especially in Nebraska, where opposition to transporting crude from the oil sands of Canada has delayed a national decision on the project.
Even If Keystone Pipeline Rejected, Oil May Still Cross Neb. By Rail
i i
hide captionThe EPA is proposing rules that would govern carbon dioxide gas emissions by U.S. power plants. Here, coal is transported via conveyor belt to the coal-fired Jim Bridger Power Plant outside Point of the Rocks, Wyo., in March.
Jim…
EPA Unveils New Proposal Targeting Greenhouse Gases
Nipah virus and Hendra virus are closely related and following natural or experimental exposure induce similar clinical disease. In humans, encephalitis is the most serious outcome of infection and, hitherto, research into the pathogenesis of henipavirus encephalitis has been limited by the…
Subclinical infection without encephalitis in mice following intranasal exposure to Nipah virus-Malaysia and Nipah virus-Bangladesh
Alzheimer’s disease (AD) is a progressive, incurable neurodegenerative disease and the most commontype of dementia. It cannot be prevented, cured or drastically slowed, even though AD research hasincreased in the past 5-10 years.
Instead of focusing on the brain volume or on the single…
Brain region’s relative proximity as marker for Alzheimer’s disease based on structural MRI
Allogeneic stem cell transplant recipients are prone to infections by various organisms. Tuberculosis (TB) represents a rare infectious complication, especially in countries non-endemic for TB.Case report: Here, we report the case of a German patient with exposure to TB decades before he was…
Synchronous tuberculosis, Epstein-Barr virus-associated lymphoproliferative disorder and cytomegalovirus infection in an allogeneic transplant recipient: a case report
Djungarian hamster (P. sungorus) and Roborovskii hamster (P.
roborovskii) belong to the same genus of phodopus. Roborovskii hamster shows high locomotor activity and low level of dopamine (DA) in the brain.
Administration of L-tyrosine, a precursor of DA, decreases locomotor activity in…
Metabolism of amino acids differs in the brains of Djungarian hamster (P. sungorus) and Roborovskii hamster (P. roborovskii)
The Patient Satisfaction Questionnaire (PSQ) is an assessment tool used to evaluate patients’perspectives of their doctor’s communication and interpersonal skills. The present pilot study investigated whether the PSQ could be administered successfully in a hospice inpatient setting…
Is the patient satisfaction questionnaire an acceptable tool for use in a hospice inpatient setting?: a pilot study
“Since our work shows we can reverse the processes that weaken synapses, we could potentially counteract some of the beta amyloid’s effects in Alzheimer’s patients.” Scientists optically stimulated a group of nerves in a rat’s brain that had been genetically…
Source:Scientists to bring back the lost memories of Alzheimer’s patients
A new treatment has been shown to extend the lifespans of men with advanced prostate cancer by as much as one year, researchers said Sunday.
The study involved 790 men who were diagnosed with metastatic prostate cancer, meaning the disease had spread beyond the prostate.
By adding the…
Treatment extends life for men with prostate cancer
