Researchers identify immune dysfunction as a possible aspect of polycystic ovary syndrome pathology

The peripubertal DHT-induced mouse model is a non-obese but insulin-resistant model of PCOS. a) Experimental design. b) Fat mass. c) Insulin levels at baseline and 15 min following glucose administration. d) Blood glucose levels during oGTT. e) HOMA-IR, calculated from fasted glucose and insulin levels. f) Glycosylated hemoglobin levels (HbA1c). Credit: Advanced Science (2024). DOI: 10.1002/advs.202401772 A new study shows that hyperandrogenism—a key characteristic of polycystic ovary syndrome (PCOS)—affects immune cell populations in reproductive, metabolic and immunological tissues in a PCOS-like mouse model. These findings are of great importance as Read More