Quantitative imaging reveals collagen changes in melanoma tumors during immunotherapy

Imaging during immunotherapy treatment reveals changes in collagen. Credit: Alexa R. Heaton, Nate J. Burkard, and Matt Stefely Collagen, a major component of the extracellular matrix, plays a crucial role in tumor development. During the development of tumors (“tumorigenesis”), collagen fibers become linearized and densely deposited, hindering immune cell infiltration and promoting tumor metastasis. However, quantifying these collagen changes during melanoma progression has been challenging. As reported in Biophotonics Discovery, researchers from the Morgridge Institute for Research and University of Wisconsin—Madison recently addressed this challenge by using quantitative imaging to Read More