New insights into the evolution of the prion protein could guide future neurodegenerative disease research

Liquid-liquid phase separation of full-length PrP is promoted by the tryptophans in the octarepeat and not influenced by copper. A, schematic presentation of WT MoPrP. B, schematic presentation of MoPrP-OR?H. C, schematic presentation of MoPrP-OR?W. D, ten µM of WT MoPrP in 10 mM Tris–HCl. E, ten µM of WT MoN1 in 10 mM Tris–HCl. Credit: Journal of Biological Chemistry (2024). DOI: 10.1016/j.jbc.2024.107310 A study from Bochum describes a mammal-specific domain of the prion protein and offers new approaches for research into neurodegenerative diseases. Prion diseases are progressive and invariably Read More