Study identifies metabolic inflexibility that keeps damage at bay during liver regeneration

Researchers used fluorescents on a regenerative liver. Blue is DAPI, a nuclear marker. Green is HNF4?, a hepatocyte marker. Red is BrdU, marking proliferating cells. White is CK19, a bile duct marker. Credit: UT Southwestern Medical Center Liver cells have a vital metabolic inflexibility during regeneration to starve dysfunctional cells and keep damage from spreading, according to new research from Children’s Medical Center Research Institute at UT Southwestern (CRI) published in Science. CRI Associate Professor Prashant Mishra, M.D., Ph.D., Xun Wang, Ph.D., and colleagues have found that hepatocytes, the cells responsible for most liver function, normally use their mitochondria to process Read More