X-linked human genetic variation associated with skewed X chromosome usage in blood-derived polyclonal B lymphoblastoid cells. Credit: Nature Genetics (2024). DOI: 10.1038/s41588-024-01840-5 A study published in Nature Genetics by the Lymphoid Development Group at the MRC Laboratory of Medical Sciences reveals that the contribution of cells expressing maternal or paternal X chromosomes can be selectively skewed in different parts of the body. The study leverages human data from the 1000 Genomes Project combined with mouse models of human X chromosome-linked DNA sequence variation to advance our fundamental understanding of development in biologically female individuals who have two X chromosomes. Until Read More
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