Monday, January 27, 2025

Immune cell transformation can influence stem cell transplant success in cancer patients

Ex vivo expanded murine ILC2s exhibit the phenotypic and functional properties of ILC2s. Credit: Nature Communications (2024). DOI: 10.1038/s41467-024-50263-7 Researchers at UNC Lineberger Comprehensive Cancer Center and colleagues have determined that a specific type of immune cell—type II innate lymphoid cells (ILC2s)—can change its characteristics and functions after a cancer patient receives stem cells from a donor, thereby preventing an effective, healthy rebuilding of the immune system. This new understanding of ILC2 cells’ transformational flexibility could lead to better strategies for enhancing immune system recovery post-transplantation. The finding appeared July 17, 2024, in Nature Communications. In the U.S., there have Read More

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