Prognostic and therapeutic insights into MIF, DDT, and CD74 in melanoma

Tumor infiltrating immune cell profiling according to high (cyan) and low (salmon) CD74:MIF levels (A) and CD74:DDT levels (B) using TIMER2.0 deconvolution analysis. Credit: 2024 Valdez et al. A new research paper was published in Oncotarget entitled, “Prognostic and therapeutic insights into MIF, DDT, and CD74 in melanoma.” Macrophage Migration Inhibitory Factor (MIF) and its homolog D-dopachrome Tautomerase (DDT) have been implicated as drivers of tumor progression across a variety of cancers. Recent evidence suggests MIF as a therapeutic target in immune checkpoint inhibition (ICI) resistant melanomas. However, clinical evidence of MIF and particularly of DDT remains limited. In this Read More