Spatial arrangement of three immune cells is key to attacking tumors

Graphical abstract. Credit: Cancer Cell (2024). DOI: 10.1016/j.ccell.2024.05.025 There’s a frustrating fact about today’s immunotherapies for cancer. While sometimes they work beautifully—completely eliminating or greatly reducing cancer in particular patients—other times they don’t work at all. It’s a mystery. Scientists have posed several hypotheses to explain the disparity. Perhaps it’s the number of mutations present in a tumor, with more mutations leading to better responses. Or maybe it’s the tissue environment surrounding the tumor, with some environments supporting and others suppressing effective immune responses. But so far, none of these explanations has proved definitive or applicable in all cases. Researchers Read More