5 Must-Reads To Get You Through February

The Invention of Wings

By Sue Monk Kidd

384 pages; Viking

This powerful story about the relationship between Sarah Grimké and her household slave, Hetty—known around the Grimké estate as Handful for her rebellious disposition—explores the rigid social order of early-19th-century…

5 Must-Reads To Get You Through February

RNAi-based screening offers MPM treatment hope

By Kirsty Oswald, medwireNews Reporter

Research using RNA interference (RNAi)-based screening has identified several potential targets for the treatment of malignant pleural mesothelioma (MPM).

The study authors, led by Glen Reid of the University of Sydney in New South Wales, Australia, say…

RNAi-based screening offers MPM treatment hope

Azilsartan, an angiotensin II type 1 receptor blocker, restores endothelial function by reducing vascular inflammation and by increasing the phosphorylation ratio Ser1177/Thr497 of endothelial nitric oxide synthase in diabetic mice

Azilsartan, an angiotensin II type 1 (AT1) receptor blocker (ARB), has a higher affinity for and slower dissociation from AT1 receptors and shows stronger inverse agonism compared to other ARBs. Possible benefits of azilsartan in diabetic vascular dysfunction have not been…

Azilsartan, an angiotensin II type 1 receptor blocker, restores endothelial function by reducing vascular inflammation and by increasing the phosphorylation ratio Ser1177/Thr497 of endothelial nitric oxide synthase in diabetic mice

The development and validation of an LC-MS/MS method for the determination of a new anti-malarial compound (TK900D) in human whole blood and its application to pharmacokinetic studies in mice

Malaria is one of the most lethal and life-threatening killer infectious diseases in the world, and account for the deaths of more than half a million people annually. Despite the remarkable achievement made in preventing and eradicating malaria, it still remains a threat to the public health…

The development and validation of an LC-MS/MS method for the determination of a new anti-malarial compound (TK900D) in human whole blood and its application to pharmacokinetic studies in mice

Correction: Dispelling myths about rare disease registry system development

CorrectionAfter publication of this work [1], we noted that we inadvertently failed to include important Acknowledgments in our final version of the manuscript.AcknowledgementsThe authors received funding from the Australian National Health and Medical Research Council (APP1055319) and EU FP7…

Correction: Dispelling myths about rare disease registry system development

Formative research to develop a community-based intervention for chronic disease prevention in Guatemalan school-age children

Noncommunicable diseases (NCD) are the most common causes of morbidity and mortality worldwide, even in low- and middle-income countries (LMIC). Recent trends in health promotion emphasize community-based interventions as an important strategy for improving health outcomes.

The aim of this…

Formative research to develop a community-based intervention for chronic disease prevention in Guatemalan school-age children

A metabolic biosignature of early response to anti-tuberculosis treatment

The successful treatment of tuberculosis (TB) requires long-term multidrug chemotherapy. Clinical trials to evaluate new drugs and regimens for TB treatment are protracted due to the slow clearance of Mycobacterium tuberculosis (Mtb) infection and the lack of early biomarkers to predict…

A metabolic biosignature of early response to anti-tuberculosis treatment

Why Making Comparisons Hurts You More Than It Helps

At the start of a new year, many people make resolutions and are inspired to make changes in their lives. This year my resolution is to have no resolution.

The problem with resolutions is that it can place you on a dangerous course of comparison. We constantly compare images, status, children,…

Why Making Comparisons Hurts You More Than It Helps

Limited microdiscectomy effective for disc herniation

(HealthDay)—In patients with lumbar disc herniation, limited discectomy with removal of the fragment is associated with good long-term outcomes, according to a study published in the February issue of the Journal of Spinal Disorders Techniques.

John Soliman, D.O., from the Advocate BroMenn…

Limited microdiscectomy effective for disc herniation

Improved outcomes seen with ventricular assist devices

(HealthDay)—Among Medicare patients receiving implantation of ventricular assist devices (VADs) for advanced heart failure, mortality has decreased, but readmission rates did not change, according to research published online Jan. 29 in the Journal of the American College of…

Improved outcomes seen with ventricular assist devices

College drinking may aggravate PTSD symptoms

(HealthDay)—College students with post-traumatic stress disorder (PTSD) are likely to drink more alcohol than other students, potentially worsening their symptoms and leading them to drink even more, new research suggests.

It’s estimated that 9 percent of all college students suffer…

College drinking may aggravate PTSD symptoms

Key role for Fusobacterium adhesin in non-orthodontic periodontal inflammation

By Kirsty Oswald, medwireNews Reporter

Researchers from China have found that patients with gingivitis and periodontitis are more likely to have Fusobacterium nucleatum carrying the novel Fusobacterium adhesin A (fadA) than periodontally healthy people.

The results suggest that fadA, which is…

Key role for Fusobacterium adhesin in non-orthodontic periodontal inflammation

4 Reasons You Should Totally Try a Fitness Fusion Class

Maximize your time at the gym with a fitness fusion class. Here, four reasons you should try one, from Natalie Rado, a personal trainer in New York City and owner of Be Well: Fitness By Natalie.

Burn more calories.

Your muscles are challenged in several ways as your body works to maintain the…

4 Reasons You Should Totally Try a Fitness Fusion Class

Overhaul Your Beauty Routine with Small Changes For 7 Weeks

There’s no denying the desire to hit the refresh button during this time of year—especially if you live in a part of the country where the weather is bleak. “Winter can make us feel like even our best assets are dull,” says Vivian Diller, Ph.D., author of Face It: What Women…

Overhaul Your Beauty Routine with Small Changes For 7 Weeks

U.S. Issues Keystone XL Pipeline Environmental Review

i i

hide captionPipefitters work on construction of the Keystone XL Pipeline’s southern portion outside Tulsa, Okla., last January.

PR Newswire

Pipefitters work on construction of the Keystone XL Pipeline’s southern…

U.S. Issues Keystone XL Pipeline Environmental Review

State Dept. Delivers Unwelcome News For Keystone Opponents

The U.S. State Department made a much-anticipated announcement on the Keystone XL pipeline on Friday. Its report finds that while the heavy crude oil that the pipeline will carry from Canada is dirtier than regular crude, stopping the pipeline won’t keep that crude in the ground. There are…

State Dept. Delivers Unwelcome News For Keystone Opponents

Downington Man Indicted on Firearms, Fraud Charges

Istvan Merchenthaler, 43, of Downingtown, Pennsylvania, was charged yesterday by indictment with one count of possession of unregistered firearms and one count of being a fugitive in possession of a firearm and ammunition, announced United States Attorney Zane David Memeger. Specifically,…

Downington Man Indicted on Firearms, Fraud Charges

Federalsburg Man Sentenced to 40 Years in Prison for Producing Child Pornography

BALTIMORE—United States District Judge J Frederick Motz sentenced Scott Zalewski, age 31, of Federalsburg, Maryland, today to 40 years in prison, followed by lifetime supervised release, for two counts of producing child pornography. Judge Motz ordered that upon his release from prison,…

Federalsburg Man Sentenced to 40 Years in Prison for Producing Child Pornography

Santeria Follower Convicted on Federal Drug Charges

BROWNSVILLE, TX—Francisco Javier Maya, 35, has been convicted of one count of conspiracy to possess and possession with intent to distribute approximately 1,000 pounds of marijuana, announced United States Attorney Kenneth Magidson. The verdict was returned less than an hour ago after two…

Santeria Follower Convicted on Federal Drug Charges

North Dakota Woman Charged with Theft

United States Attorney Brendan V Johnson announced that a Mandan, North Dakota woman has been indicted by a federal grand jury for theft concerning programs receiving federal funds. Dawn Muir, age 52, was indicted on January 15, 2014. She appeared before United States Magistrate Judge William…

North Dakota Woman Charged with Theft

Fruit flies reveal normal function of a gene mutated in spinocerebellar ataxia type 7

Disruptive clumps of mutated protein are often blamed for clogging cells and interfering with brain function in patients with the neurodegenerative diseases known as spinocerebellar ataxias. But a new study in fruit flies suggests that for at least one…

Source: Fruit flies reveal normal function of a gene mutated in spinocerebellar ataxia type 7

Melanoma risk up in IBD independent of biologic therapy

(HealthDay)—Inflammatory bowel disease (IBD) is associated with an increased risk of melanoma, independent of the use of biologic therapy, according to research published in the February issue of Clinical Gastroenterology and Hepatology.

Source: Melanoma risk up in IBD independent of biologic therapy

MS researchers study predictors of employment status

Researchers at Kessler Foundation have studied the measurement tools used in multiple sclerosis for their effectiveness in predicting employment status. They compared the Expanded Disability Status Scale (EDSS), the Multiple Sclerosis Functional…

Source: MS researchers study predictors of employment status

Studies find new links between sleep duration and depression

A genetic study of adult twins and a community-based study of adolescents both report novel links between sleep duration and depression. The studies are published in the Feb. 1 issue of the journal Sleep.

Source: Studies find new links between sleep duration and depression

College drinking may aggravate PTSD symptoms

(HealthDay)—College students with post-traumatic stress disorder (PTSD) are likely to drink more alcohol than other students, potentially worsening their symptoms and leading them to drink even more, new research suggests.

Source: College drinking may aggravate PTSD symptoms

Improved outcomes seen with ventricular assist devices

(HealthDay)—Among Medicare patients receiving implantation of ventricular assist devices (VADs) for advanced heart failure, mortality has decreased, but readmission rates did not change, according to research published online Jan. 29 in the Journal of…

Source: Improved outcomes seen with ventricular assist devices

Limited microdiscectomy effective for disc herniation

(HealthDay)—In patients with lumbar disc herniation, limited discectomy with removal of the fragment is associated with good long-term outcomes, according to a study published in the February issue of the Journal of Spinal Disorders & Techniques.

Source: Limited microdiscectomy effective for disc herniation

CDC to launch latest graphic anti-smoking campaign

(HealthDay)—For the third year in a row, the U.S. Centers for Disease Control and Prevention is poised to deliver a bold, no-holds-barred, anti-tobacco message to the American public.

Source: CDC to launch latest graphic anti-smoking campaign

Health reform differs across states, report finds

(HealthDay)—Californians’ experience with health reform is probably very different from that of, say, the citizens of Texas.

Source: Health reform differs across states, report finds

Super Bowl Sunday Is Heart Attack Sunday

The Super Bowl and Heart Attacks It’s an annual event. We all enjoy the pre-game hype, anticipate a round of fabulous television commercials and look forward to seeing what the Clydesdales will do next. As the public prepares for the big game, doctors and nurses in hospital emergency rooms…

Source:Super Bowl Sunday Is Heart Attack Sunday

Breast Cancer Survivor Allison Gryphon: Don't Call Me Brave

When novelist and filmmaker Allison Gryphon was diagnosed with breast cancer, friends kept telling her the same thing — that she was brave. It’s a compliment that is meaningful and significant to her, but as Gryphon explained on HuffPost Live, at times it could be crushing to…

Source:Breast Cancer Survivor Allison Gryphon: Don’t Call Me Brave

Please, Carry Omm

If you’re a high energy, quintuple A personality like me, then perhaps you can relate to my years of frustration, futilely embarking on countless quests to find a Holy Grail of inward bliss through meditation. I was a woman on a mission. Truth be told, I never lasted more than 10 seconds…

Source:Please, Carry Omm

Go the Extra Mile: Run for Yourself, Run for a Cause

Running. You either love it or you hate it. You love feeling the wind on your face, the pounding of your feet against the pavement, the rush of blood through your veins and the way your post-workout endorphins make you feel. You hate feeling out of breath, getting out of bed in the morning when…

Source:Go the Extra Mile: Run for Yourself, Run for a Cause

Studies find new links between sleep duration and depression

[ | E-mail ] Contact: Lynn Celmerlcelmer@aasmnet.org 630-737-9700American Academy of Sleep Medicine Sub-optimal sleep may activate depressive genes, increase risk for major depression IMAGE: This is a photo of Nathaniel F. Watson, MD, associate professor of neurology and…

Source:Studies find new links between sleep duration and depression

Dartmouth scientists develop protocol to harvest mouse cell lines for melanoma research

[ | E-mail ] Contact: Robin DutcherRobin.Dutcher@hitchcock.org 603-653-9003The Geisel School of Medicine at Dartmouth Dartmouth researchers have developed a protocol that permits cells harvested from melanoma tumors in mice to grow readily in cell culture. Their findings were published…

Source:Dartmouth scientists develop protocol to harvest mouse cell lines for melanoma research

NASA catches Tropical Depression Kajiki over central Philippines

[ | E-mail ] Contact: Rob Gutrorobert.j.gutro@nasa.govNASA/Goddard Space Flight Center IMAGE: The AIRS instrument aboard NASA’s Aqua satellite captured cloud top temperatures with infrared data on Tropical Depression Kajiki on Jan. 31 at 04:41 UTC, showing powerful…

Source:NASA catches Tropical Depression Kajiki over central Philippines

NASA's Aqua satellite sees System 91S struggling

[ | E-mail ] Contact: Rob Gutrorobert.j.gutro@nasa.govNASA/Goddard Space Flight Center IMAGE: This false-colored infrared image from the MODIS instrument aboard NASA’s Aqua satellite shows the strongest thunderstorms associated with System 91S to the west-northwest…

Source:NASA’s Aqua satellite sees System 91S struggling

Dormant prostate cancer cells may be reawakened by factors produced in inflammatory cells

[ | E-mail ] Contact: Cara Martinezcara.martinez@cshs.org 310-423-7798Cedars-Sinai Medical Center LOS ANGELES (Jan. 31, 2014) Researchers in the Cedars-Sinai Samuel Oschin Comprehensive Cancer Institute discovered in pre-clinical models that dormant prostate cancer cells found in bone…

Source:Dormant prostate cancer cells may be reawakened by factors produced in inflammatory cells

Down to EARTH: Interview with Department of the Interior Secretary, Sally Jewell

[ | E-mail ] Contact: Maureen Mosesmmoses@agiweb.org 703-379-2480American Geosciences Institute Alexandria, VA EARTH Magazine sits down with Secretary of the Interior Sally Jewell to discuss the role of geoscience at the Department of the Interior, including the National Park Service,…

Source:Down to EARTH: Interview with Department of the Interior Secretary, Sally Jewell

Competing Attack Ads in Florida Miss Mark

Competing attack ads ask what voters “really know” about Florida congressional candidates Alex Sink and David Jolly. But don’t count on the ads to clear things up, as both rely on misleading claims. An ad from the Sink campaign attacks Jolly’s lobbying past, but uses thinly…

Source:Competing Attack Ads in Florida Miss Mark

Super Bowl Sunday Is Heart Attack Sunday

The Super Bowl and Heart Attacks

It’s an annual event. We all enjoy the pre-game hype, anticipate a round of fabulous television commercials and look forward to seeing what the Clydesdales will do next. As the public prepares for the big game, doctors and nurses in hospital emergency rooms…

Super Bowl Sunday Is Heart Attack Sunday

Breast Cancer Survivor Allison Gryphon: Don’t Call Me Brave

When novelist and filmmaker Allison Gryphon was diagnosed with breast cancer, friends kept telling her the same thing — that she was brave. It’s a compliment that is meaningful and significant to her, but as Gryphon explained on HuffPost Live, at times it could be crushing to…

Breast Cancer Survivor Allison Gryphon: Don’t Call Me Brave

Please, Carry Omm

If you’re a high energy, quintuple A personality like me, then perhaps you can relate to my years of frustration, futilely embarking on countless quests to find a Holy Grail of inward bliss through meditation. I was a woman on a mission. Truth be told, I never lasted more than 10 seconds…

Please, Carry Omm

Go the Extra Mile: Run for Yourself, Run for a Cause

Running. You either love it or you hate it. You love feeling the wind on your face, the pounding of your feet against the pavement, the rush of blood through your veins and the way your post-workout endorphins make you feel. You hate feeling out of breath, getting out of bed in the morning when…

Go the Extra Mile: Run for Yourself, Run for a Cause

Studies find new links between sleep duration and depression

[

| E-mail

]

Contact: Lynn Celmerlcelmer@aasmnet.org

630-737-9700American Academy of Sleep Medicine

Sub-optimal sleep may activate depressive genes, increase risk for major depression

IMAGE:

This is a photo of Nathaniel F. Watson, MD, associate professor of neurology and…

Studies find new links between sleep duration and depression