Research team resolves structure of crucial enzyme for the first time

Functional characterization and architecture of human HGSNAT. Credit: Nature Structural & Molecular Biology (2024). DOI: 10.1038/s41594-024-01315-5 For the first time, a team co-led by CHU Sainte-Justine researcher and professor in the Faculty of Medicine at Université de Montréal, Alexey Pshezhetsky has succeeded in resolving the unique structure of the HGSNAT enzyme, a deficiency of which causes Sanfilippo syndrome, a rare pediatric disease affecting the central nervous system. Through collaboration with a team from Shanghai University, the structure of this enzyme and the mechanism of its function were revealed using high-performance Read More