Accumulation of ?-amyloid (A?) in the brain is essential to Alzheimer?s disease (AD) pathogenesis. Carriers of the apolipoprotein E (APOE) ?4 allele demonstrate greatly increased AD risk and enhanced brain A? deposition.
In contrast, APOE ?2 allele carries show reduced AD risk, later age of…
Blocking the apoE/Abeta interaction ameliorates Abeta-related pathology in APOE epsilon2 and epsilon4 targeted replacement Alzheimer model mice
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