The importance of a large sample cohort for studies on modifier genes influencing disease severity in FAP patients

Familial adenomatous polyposis (FAP) is usually characterised by the appearance of hundreds-to-thousands of adenomas throughout the colon and rectum and if left untreated the condition will develop into CRC with close to 100% penetrance. Germline mutations in the APC gene, which plays an…

Source:The importance of a large sample cohort for studies on modifier genes influencing disease severity in FAP patients