Using inactivating mutations to provide insight into drug action

Cardiovascular diseases (CVDs) are the primary cause of death globally 1]. In 2008, 30% of all global deaths were attributed to CVDs, including an estimated 7.3 million deaths caused by coronary heart disease (CHD) 1]. As a major risk factor for CHD, increased circulating cholesterol – p…

Source:Using inactivating mutations to provide insight into drug action