The S-phase checkpoint aims to prevent cells from generation of extensive single-stranded DNA that predisposes to genome instability. The S. cerevisiae complex Tof1/Csm3/Mrc1 acts to restrain the replicative MCM helicase when DNA synthesis is prohibited. Keeping the replication machinery…
Source:The subunits of the S-phase checkpoint complex Mrc1/Tof1/Csm3: dynamics and interdependence
Thursday, October 30, 2014
The subunits of the S-phase checkpoint complex Mrc1/Tof1/Csm3: dynamics and interdependence
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